EB Pharma, LLC., a subsidiary of Eiger BioPharmaceuticals, Inc., today announced that it has executed an agreement with Janssen Pharmaceutica NV, ("Janssen"), for an exclusive license, to tipifarnib in the field of virology and a related, clinical stage back-up compound. EB Pharma is conducting clinical studies in patients infected with Hepatitis Delta (HDV) and will assess the efficacy and tolerability of tipifarnib as a potential new therapy.
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"This novel approach to treating HDV is the culmination of decades of research," said Jeffrey Glenn, MD, PhD, Scientific Founder and Associate Professor of Medicine, Stanford University. "I think it has the potential to change the treatment paradigm for the worst form of human viral hepatitis, and offers new hope for these patients."
"HDV is the least common but has the poorest outcome of all forms of viral hepatitis," said David Cory, President and Chief Executive Officer of Eiger. "We are excited to license tipifarnib from Janssen and study a potential new therapy for this life threatening disease."
Tipifarnib is not approved for sale for any indication.
About HDV
Hepatitis Delta is caused by infection with the hepatitis D virus (HDV) and is considered to be the most severe form of viral hepatitis in humans. Hepatitis D occurs only as a co-infection in individuals with hepatitis B (HBV), leads to more severe liver disease than HBV alone, and is associated with accelerated liver fibrosis, liver cancer, and liver failure. HDV is a disease with a significant impact on global health affecting ~15 million people worldwide. The prevalence of HDV varies between different parts of the world. HDV meets criteria for Orphan Designation in the United States (less than 200,000 people), Europe (less than 5 in 100,000 people), and Japan (less than 50,000 people). Globally, HDV infection is reported to be present in approximately 4% - 6% of chronic hepatitis B carriers. In some parts of the world, including certain areas of China, Russia, Central Asia, Turkey, Africa, and South America, prevalence as high as 40% has been reported in HBV infected patients.
About EB Pharma
EB Pharma is a privately held subsidiary of Eiger BioPharmaceuticals, Inc., focused on the research, development and commercialization of innovative therapies in viral hepatitis. The company will focus on developing tipifarnib for the treatment of Hepatitis Delta Virus (HDV), the most severe form of viral hepatitis. Tipifarnib is not approved for sale. EB Pharma's research programs are focused on the discovery of targeted, small-molecule therapeutics and biomarkers to treat and monitor serious liver diseases.
Investors: Jim Shaffer, Eiger Bio, Inc., +1-919-345-4256, [email protected]
บริษัทจะมอบวัคซีนแบบฉีดครั้งเดียวจำนวนสูงสุด 400 ล้านโดสให้ประเทศสมาชิกสหภาพแอฟริกา วัคซีนดังกล่าวจะมอบให้ได้ก็ต่อเมื่อได้รับการอนุมัติจากฝ่ายกำกับดูแลของแต่ละประเทศ ข้อมูลแสดงให้เห็นว่า วัคซีนทดลองที่บริษัทเป็นผู้พัฒนาช่วยป้องกันไม่ให้ผู้ป่วยโควิด-19 ต้องเข้าโรงพยาบาลและเสียชีวิตครอบคลุมหลากหลายพื้นที่ทางภูมิศาสตร์ ซึ่งรวมถึงผู้ติดเชื้อไวรัสกลายพันธุ์ในสายพันธุ์ที่กำลังน่าเป็นห่วง Janssen Pharmaceutica NV ในเครือ Janssen Pharmaceutical Companies of Johnson & Johnson (NYSE: JNJ) (บริษัท)